Simulating normal operation is something that's been done for a while now, ever since computers got powerful enough to do it. Once validated, a model of, say, a stirred tank, will let an engineer consider where two liquids being mixed are not mixing properly, or where fragile solids are likely to be broken because the shear is high, and adjust the design accordingly before the manufacturer ever cuts metal.
I started by talking about fluid dynamics simulation because that and chemical reaction simulation are the two aspects I'm most likely to work with. Other simulations which could affect me but are outside of my field are materials and mechanical related - pipe and tank fractures, for example. The stresses and weak points of a piece of equipment are something I have to trust to a mechanical engineer, but I have to think about it at least a bit, because what's inside those tanks and pipes is sometimes hot, sometimes toxic, sometimes corrosive, or other forms of dangerous and undesirable to have present outside the equipment, and I have to know what kind of safety features and procedures I have to put in place, from sensors to detect a small leak to secondary containment to prevent a catastrophic spill from escaping and doing even more damage.


